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Inventions by MVP Scientists

No.

Patents (issued or pending) by MVP scientists
1

Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2008)
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
US Patent Application 2008/00058246 A1

2

Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2008)

        Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
        US Patent Application
2008/0057048 A1

3

Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2008)

        PEG-urate oxidase conjugates and use thereof.
        US Patent Application
2008/0031864 A1

4

Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGS, French JA (2007)

        Polymer conjugates of proteinases.
        US Patent
7,229,810 B1

5 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2005)
        PEG-urate oxidase conjugates and use thereof.

        European Patent Specification
EP 1 100 542 B1
6 Sherman MR, Saifer MGP, Williams LD (2005).
        Aggregate-free protein compositions and methods of preparing same.
        US Patent Application 2005/0014240 A1 
7

Sherman MR, Saifer MGP, Williams LD (2004).
       
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.

        US Patent  6,783,965 B1 

8

Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2004)
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
PCT Publication WO 2004/060300 A2

9

Saifer MGP, Martinez AL , Williams LD, Sherman MR (2004)
Polymer conjugates of interferon-beta with enhanced biological potency.
PCT Publication WO 2004/060299 A2

10

Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2004)
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
US Patent Application 2004/0136952 A1

11 Saifer MGP, Martinez AL, Williams LD, Sherman MR,  (2004)
        Polymer conjugates of interferon-beta with enhanced biological potency.
        US Patent Application  2004/0126361 A1
12 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2004)
        Polymer conjugates with decreased antigenicity, methods of preparation and use.
        US Patent Application  2004/0062746 A1
13

Martinez AL, Sherman MR, Saifer MGP, Williams LD (2004)
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof.
PCT Publication WO 04/030617 A2

14 Saifer MGP, Williams LD (2004)
        Quantitative detection of viruses by light scattering.
        European Patent Specification EP 1 218 722 B1
15 Williams LD, Hershfield M, Kelly  SJ, Saifer MGP, Sherman MR (2003).
        PEG-urate oxidase conjugates and use thereof.
        US Patent Application 2003/0166249 A1
16 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2003).
        PEG-urate oxidase conjugates and use thereof.
        US Patent  6,576,235 B1
17 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MG, French  JA (2003)
        Polymer conjugates of proteinases.
        US Patent Application 2003/0012777 A1
18 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGP (2003)
        Polymer stabilized proteinases
        PCT Publication WO 03/002716 A2
19

Saifer MGP, Williams LD (2003)
        Quantitation of viruses by light scattering.
        US Patent 6,544,770 B2

20 Saifer MGP, Williams LD (2002)
        Quantitation of viruses by light scattering.
        US Patent Application
2002/0028439 A1
21

Sherman MR, Saifer MGP, Williams LD (2001)
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
PCT Publication WO 01/59078 A2

22

Saifer MGP, Williams LD (2001)
Quantitation of viruses by light scattering.
US Patent 6,316,185 B1

23 Saifer MGP, Williams LD (2001)
         Quantitative Detection of Viruses by Light Scattering
         PCT Publication WO 01/38852 A1
24

Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman, MR (2000)
PEG-urate oxidase conjugates and use thereof.
PCT Publication WO 00/07629 A2

25

Saifer M, Somack R, Williams LD (1995)
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,468,478

26

Saifer M, Somack R, Williams LD (1994)
Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols.
US Patent 5,283,317

27

Saifer M, Somack R, Williams LD (1992)
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,080,891

28

Saifer M, Somack R, Williams LD (1991)
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,006,333; issued in 24 additional countries

29

Huber W, Saifer MGP, Williams LD (1978)
N-Carbamylated orgotein.
US Patent 4,070,459; issued in seven additional countries

30

Huber W, Saifer MGP, Williams LD (1977)
Alkylated orgotein.
U S Patent 4,042,689; issued in seven additional countries

31

Huber W, Saifer MGP, Williams LD (1977)
Esterified orgotein.
US Patent 4,022,888; issued in seven additional countries

32

Huber W, Saifer MGP, Williams LD (1977)
Radioactive labeled orgotein.
US Patent 4,022,877; also issued in
Canada

33

Saifer MGP, Williams LD, Huber W (1977)
Reduction of superoxide accumulation caused by smoke inhalation.
US Patent 4,022,224

34

Huber W, Saifer MGP, Williams LD (1977)
Acylated orgotein.
US Patent 4,017,605; issued in 14 additional countries

35

Huber W, Saifer MGP, Williams LD (1977)
Cross-linked orgotein.
US Patent 4,009,267; issued in eight additional countries

36

Huber W, Chow S H, Saifer MGP (1974)
Enzymatic treatment of protein mixtures containing orgotein.
US Patent 3,806,411; issued in 25 additional countries