INVENTIONS

No. U.S. and European Patents and Patent Applications by MVP Scientists
1 Martinez AL, Sherman MR. Saifer MGP, Williams LD (2017) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof. 
US Patent Application 2017/0189544 A1 For license opportunity, contact busdev@mvpharm.com.
2 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2016) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2016/0160188 A1
3 Saifer MGP, Martinez AL, Williams LD, Sherman MR (2015) Polymer conjugates of interferon-beta with enhanced biological potency.
U.S. Patent No. 9,125,880 B2. For license opportunity, contact busdev@mvpharm.com
4 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2014) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
US Patent Application 2014/0363414 A1
5 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2014) Conjugates prepared with aggregate-free proteins.
European Patent Specification EP 2 305 819 B1; validated in 20 countries.
6 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2014) Method for purifying urate oxidase tetramers and octamers. US Patent 8,921,064 B2
7 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2014) Conjugates prepared with aggregate-free proteins.
European Patent Specification EP 2 196 538 B1; validated in 11 countries. For license opportunity, contact busdev@mvpharm.com.
8 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2014) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof.
European Patent Specification EP 1 572 728 B1; validated in 22 countries. For license opportunity, contact busdev@mvpharm.com.
9 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2013) PEG-urate oxidase conjugates and use thereof.
US Patent 8,618,267 B2
10 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2013) PEG-urate oxidase conjugates and use thereof.
European Patent Specification EP 2 158 923 B1; validated in 19 countries.
11 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2013) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2013/0052677 A1
12 Saifer MGP, Martinez AL, Williams LD, Sherman MR (2012) Polyethylene glycol conjugates of interferon-beta-1b with enhanced in vitro biological potency.
European Patent Specification EP 1 667 708 B9; validated in 22 countries. For license opportunity, contact busdev@mvpharm.com.
13 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2012) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2012/0149083 A1
14 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2012) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof.
US Patent Application 2012/0114742 A1 For license opportunity, contact busdev@mvpharm.com.
15 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2012) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof.
US Patent 8,129,330 B2 For license opportunity, contact busdev@mvpharm.com.
16 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2011) PEG-urate oxidase conjugates and use thereof.
US Patent 8,067,553 B2
17 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2011) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
US Patent Application 2011/0287466 A1
18 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2011) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
US Patent 7,927,852 B2
19 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2011) PEG-urate oxidase conjugates and use thereof.
US Patent 7,927,589 B2
20 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2011) PEG-urate oxidase conjugates and use thereof.
European Patent Specification EP 1 588 716 B1;
validated in 19 countries.
21 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2010) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
European Patent Specification EP 1 254 237 B1; validated in 20 countries.
22 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2010) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2010/323423 A1
23 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2010) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2010/323422 A1
24 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2010) PEG-urate oxidase conjugates and use thereof.
US Patent 7,723,089 B2
25 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGS, French JA (2008) Polymer stabilized proteinases.
European Patent Specification EP 1 421 175 B1;
validated in 10 countries.  For license opportunity, contact busdev@mvpharm.com.
26 Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2008) Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
US Patent Application 2008/00058246 A1
  For license opportunity, contact busdev@mvpharm.com.
27 Sherman MR, Saifer MGP, Williams LD, Hershfield MS, Kelly SJ (2008) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
US Patent Application 2008/0057048 A1
28 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2008) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2008/0031864 A1
29 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGS, French JA (2007) Polymer conjugates of proteinases.
US Patent 7,229,810 B2
  For license opportunity, contact busdev@mvpharm.com.
30 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2005) PEG-urate oxidase conjugates and use thereof.
European Patent Specification EP 1 100 542 B1;
validated in 19 countries
31 Sherman MR, Saifer MGP, Williams LD (2005) Aggregate-free protein compositions and methods of preparing same.
US Patent Application 2005/0014240 A1
  For license opportunity, contact busdev@mvpharm.com.
32 Sherman MR, Saifer MGP, Williams LD (2004) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
US Patent 6,783,965 B1
33 Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2004) Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
PCT Publication WO 2004/060300 A2
; granted or validated in 17 countries.  For license opportunity, contact busdev@mvpharm.com.
34 Saifer MGP, Martinez AL, Williams LD, Sherman MR (2004) Polymer conjugates of interferon-beta with enhanced biological potency.
PCT Publication WO 2004/060299 A2
; granted or validated in 43 countries.  For license opportunity, contact busdev@mvpharm.com.
35 Bhaskaran SS, Sherman MR, Saifer MGP, Williams LD (2004) Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity.
US Patent Application 2004/0136952 A1
36 Saifer MGP, Martinez AL, Williams LD, Sherman MR, (2004) Polymer conjugates of interferon-beta with enhanced biological potency.
US Patent Application 2004/0126361 A1
For license opportunity, contact busdev@mvpharm.com.
37 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2004) Polymer conjugates with decreased antigenicity, methods of preparation and use.
US Patent Application 2004/0062746 A1
; patent No. 8,129,330 granted (divisional application pending). For license opportunity, contact busdev@mvpharm.com.
38 Martinez AL, Sherman MR, Saifer MGP, Williams LD (2004) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof.
PCT Publication WO 04/030617 A2
; granted or validated in 51 countries. For license opportunity, contact busdev@mvpharm.com.
39 Saifer MGP, Williams LD (2004) Quantitative detection of viruses by light scattering.
European Patent Specification EP 1 218 722 B1; validated in three countries.  For license opportunity, contact busdev@mvpharm.com.
40 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2003) PEG-urate oxidase conjugates and use thereof.
US Patent Application 2003/0166249 A1
41 Williams LD, Hershfield M, Kelly SJ, Saifer MGP, Sherman MR (2003) PEG-urate oxidase conjugates and use thereof.
US Patent 6,576,235 B1
42 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGP, French JA (2003) Polymer conjugates of proteinases.
US Patent Application 2003/0012777 A1; patent No.7,229,810 granted. For license opportunity, contact busdev@mvpharm.com.
43 Sherman MR, Martinez AL, Bhaskaran SS, Williams LD, Saifer MGP (2003) Polymer stabilized proteinases. 
PCT Publication WO 03/002716 A2
; granted in U.S. and Europe.  For license opportunity, contact busdev@mvpharm.com.
44 Saifer MGP, Williams LD (2003) Quantitation of viruses by light scattering.
US Patent 6,544,770 B2
  For license opportunity, contact busdev@mvpharm.com.
45 Saifer MGP, Williams LD (2002) Quantitation of viruses by light scattering.
US Patent Application 2002/0028439 A1
46 Sherman MR, Saifer MGP, Williams LD (2001) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
PCT Publication WO 01/59078 A2
; 70 patents granted in 38 countries.
47 Saifer MGP, Williams LD (2001) Quantitation of viruses by light scattering.
US Patent 6,316,185 B1
  For license opportunity, contact busdev@mvpharm.com.
48 Saifer MGP, Williams LD (2001) Quantitative detection of viruses by light scattering.
PCT Publication WO 01/38852 A1
; granted in U.S., Europe and Canada.  For license opportunity, contact busdev@mvpharm.com.
49 Williams LD, Hershfield MS, Kelly SJ, Saifer MGP, Sherman MR (2000) PEG-urate oxidase conjugates and use thereof.
PCT Publication WO 00/07629 A2
; 97 patents granted in 38 countries.
50 Saifer M, Somack R, Williams LD (1995) Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,468,478
(expired)
51 Saifer M, Somack R, Williams LD (1994) Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols.
US Patent 5,283,317
(expired)
52 Saifer M, Somack R, Williams LD (1992) Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,080,891
(expired)
53 Saifer M, Somack R, Williams LD (1991) Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
US Patent 5,006,333
; issued in 24 additional countries. (all expired)
54 Huber W, Saifer MGP, Williams, LD (1978) N-Carbamylated orgotein.
US Patent 4,070,459
; issued in seven additional countries. (all expired)
55 Huber W, Saifer MGP, Williams LD (1977) Alkylated orgotein.
US Patent 4,042,689
; issued in seven additional countries. (all expired)
56 Huber W, Saifer MGP, Williams LD (1977) Esterified orgotein.
US Patent 4,022,888
; issued in seven additional countries. (all expired)
57 Huber W, Saifer MGP, Williams LD (1977) Radioactive labeled orgotein.
US Patent 4,022,877
; also issued in Canada. (both expired)
58 Saifer MGP, Williams LD, Huber W (1977) Reduction of superoxide accumulation caused by smoke inhalation.
US Patent 4,022,224
(expired)
59 Huber W, Saifer MGP, Williams LD (1977) Acylated orgotein.
US Patent 4,017,605
; issued in 14 additional countries. (all expired)
60 Huber W, Saifer MGP, Williams LD (1977) Cross-linked orgotein.
US Patent 4,009,267
; issued in eight additional countries. (all expired)
61 Huber W, Chow S H, Saifer MGP (1974) Enzymatic treatment of protein mixtures containing orgotein.
US Patent 3,806,411
; issued in 25 additional countries. (all expired)